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Specificity of deoxycytidylate antibodies

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1981 India English Publisher:Elsevier BVJournal:Immunology Letters, volume 3, pages 231-235 (issn: 0165-2478,

Authors: Reddy, M Vijayaraj; Jacob, TM;

doi: 10.1016/0165-2478(81)90080-8

pmid: 7309133

Specificity of deoxycytidylate antibodies

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Abstract

Antibodies to deoxycytidylate (dpC) were elicited in rabbits using a thyroglobulin (Tg) conjugate of dpC. The specificity of the antibodies was determined by measuring the inhibition of the binding of [3H]dpC to the antibodies by various non-radioactive nucleotides or derivatives. The antibodies were found to distinguish dpC from pC and DNA from RNA, probably due to their specificity for the conformation of the deoxycytidylate.

Country

India

Related Organizations

Indian Institute of Science Bangalore
India

Keywords

Cytosine Nucleotides, Biochemistry, Binding, Competitive, Deoxycytidine, Cytosine, Deoxyadenine Nucleotides, Antibody Specificity, Antibody Formation, Deoxycytosine Nucleotides, Animals, Thymine Nucleotides, Rabbits, Deoxyuracil Nucleotides

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