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The hypothalamic-pituitary-adrenal axis in anorexia nervosa

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1996 English Publisher:Elsevier BVJournal:Psychiatry Research, volume 62, pages 75-83 (issn: 0165-1781,

Authors: Licinio, Júlio; Wong, Ma-Li; Gold, Philip W.;

doi: 10.1016/0165-1781(96)02991-5

pmid: 8739117

The hypothalamic-pituitary-adrenal axis in anorexia nervosa

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Abstract

Studies examining the function of the hypothalamic-pituitary-adrenal (HPA) axis in anorexia nervosa are reviewed. A principal finding is that of hypercortisolism, associated with increased central corticotropin-releasing hormone levels and normal circulating levels of adrenocorticotropic hormone. Similarities between neuroendocrine findings in anorexia nervosa and in affective disorder are reviewed. The contribution of circadian rhythm disturbances and malnutrition to observed HPA axis abnormalities in anorexia nervosa is also considered. Directions for future research are discussed.

Related Organizations

National Institute of Mental Health
United States
National Institutes of Health
United States

Keywords

Depressive Disorder, Hypothalamo-Hypophyseal System, Anorexia Nervosa, Adrenocorticotropic Hormone, Hydrocortisone, Corticotropin-Releasing Hormone, Humans, Pituitary-Adrenal System, Motor Activity, Circadian Rhythm

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	135
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%