
Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.
Models, Molecular, Biochemistry, Genetics and Molecular Biology(all), Cell Survival, Calcium-Binding Proteins, Cell Membrane, Muscle Proteins, Receptor Protein-Tyrosine Kinases, Ryanodine Receptor Calcium Release Channel, Inositol 1,4,5-Trisphosphate, Calcium-Transporting ATPases, Endoplasmic Reticulum, Phosphatidylinositols, Models, Biological, Mitochondria, Calmodulin, GTP-Binding Proteins, Organ Specificity, Cell Movement, Animals, Humans, Calcium, Calcium Channels, Calcium Signaling, Cell Division, Signal Transduction
Models, Molecular, Biochemistry, Genetics and Molecular Biology(all), Cell Survival, Calcium-Binding Proteins, Cell Membrane, Muscle Proteins, Receptor Protein-Tyrosine Kinases, Ryanodine Receptor Calcium Release Channel, Inositol 1,4,5-Trisphosphate, Calcium-Transporting ATPases, Endoplasmic Reticulum, Phosphatidylinositols, Models, Biological, Mitochondria, Calmodulin, GTP-Binding Proteins, Organ Specificity, Cell Movement, Animals, Humans, Calcium, Calcium Channels, Calcium Signaling, Cell Division, Signal Transduction
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