Nifedipine in bronchial asthma
Copyright policy )Nifedipine in bronchial asthma
In 11 patients with bronchial asthma and regular overnight falls in PEFR of greater than 15%, we demonstrated significant bronchodilation restricted only to large airways after the administration of a single dose of 10 mg of nifedipine. A statistically significant increase in PEFR, SGaw, and FEV1 was noticed at 1 and especially 2 hr after nifedipine administration. During 4 days of nifedipine treatment (10 mg t.i.d.), the overnight fall in mean PEFR was statistically significant (p less than 0.02) and less than the mean fall of PEFR during the 4 days of placebo treatment. Thus nifedipine does modify the basal bronchial tone of patients with asthma and diminishes the circadian swing of airway resistance.
Adult, Male, Clinical Trials as Topic, Nifedipine, Pyridines, Airway Resistance, Peak Expiratory Flow Rate, Middle Aged, Asthma, Drug Administration Schedule, Circadian Rhythm, Placebos, Humans, Female, Aged
Adult, Male, Clinical Trials as Topic, Nifedipine, Pyridines, Airway Resistance, Peak Expiratory Flow Rate, Middle Aged, Asthma, Drug Administration Schedule, Circadian Rhythm, Placebos, Humans, Female, Aged
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