Effect of propranolol on the isoproterenol, responses of cortisol, isoproterenol, and aminophylline
Copyright policy )Effect of propranolol on the isoproterenol, responses of cortisol, isoproterenol, and aminophylline
Abstract We have studied the effect of propranolol on the eosinopenic responses of cortisol, isoproterenol, and aminophylline. Blood was drawn for a base-line total eosinophil count (TEC) from fasting male volunteers at 8 a.m. followed by propranolol, 40 mg., or a placebo orally. Later, one drug or a placebo was given according to the following schedule: cortisol, 25 mg. intravenously at 9 a.m., isoproterenol, 0.05 mg. subcutaneously at 11 a.m., and aminophylline, 500 mg. intravenously at noon. A second base-line TEC was obtained at 11 a.m., and a final TEC was obtained in, all patients at 1 p.m. When only placebos were given, a significant mean fall in the TEC of 14 per cent was seen in the first 3 hours (p
- Harvard University United States
Adult, Male, Adolescent, Hydrocortisone, Injections, Subcutaneous, Premedication, Isoproterenol, Administration, Oral, Aminophylline, Propranolol, Eosinophils, Placebos, Leukocyte Count, Injections, Intravenous, Humans, Drug Antagonism
Adult, Male, Adolescent, Hydrocortisone, Injections, Subcutaneous, Premedication, Isoproterenol, Administration, Oral, Aminophylline, Propranolol, Eosinophils, Placebos, Leukocyte Count, Injections, Intravenous, Humans, Drug Antagonism
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