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PGI2: A potential mediator of inflammation

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1978Publisher:Elsevier BVJournal:Prostaglandins, volume 16, pages 253-258 (issn: 0090-6980,

Authors: M. J. H. Smith; E.M. Davidson; J. R. Walker; A. W. Ford‐Hutchinson;

doi: 10.1016/0090-6980(78)90027-8

pmid: 360303

PGI2: A potential mediator of inflammation

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Abstract

PGI2, but not its metabolite 6oxoPGF1alpha, is equivalent in potency to PGE1 as a potentiator of carrageenan, histamine and bradykinin-induced rat paw oedemas. PGI2 must, therefore, be considered as a potential mediator of inflammatory processes.

Related Organizations

University of Cambridge
United Kingdom

Keywords

Prostaglandins E, Drug Synergism, Bradykinin, Carrageenan, Epoprostenol, Hindlimb, Injections, Rats, Prostaglandins, Animals, Edema, Female, Histamine

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	55
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%