descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1989 English Publisher:Elsevier BVJournal:Thrombosis Research, volume 56, pages 661-665 (issn: 0049-3848,

Authors: Ken Wada; Wataru Tatewaki; Hoyu Takahashi; Shin-ichiro Takizawa; Akira Shibata;

doi: 10.1016/0049-3848(89)90283-1

pmid: 2534445

Plasmin-a2-plasmin inhibitor complex in plasma of patients with thromboembolic diseases

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Abstract

Plasmin generation in vivo was assessed by measuring plasma levels of plasmin-a2-plasmin inhibitor complex (PAP) with an ELISA in 42 patients with arterial or venous thromboembolic diseases. Plasma concentration of PAP was markedly elevated in patients with venous thromboembolic diseases during acute illness (3.32 +/- 3.71 ug/ml, mean +/- SD) as compared to healthy subjects (0.24 +/- 0.13 ug/ml, n = 14), while it was nearly normal (0.30 +/- 0.13 ug/ml) in patients with venous thromboembolic diseases in chronic stage. Patients with arterial thromboembolism had modestly elevated PAP; 1.05 +/- 0.77 ug/ml during acute episode, and 0.84 +/- 0.40 ug/ml in chronic stage. These results indicate that excessive activation of fibrinolytic system (plasmin generation in vivo) occurs actually in many patients with thrombotic diseases, especially in venous thromboembolic diseases during acute illness.

Related Organizations

Niigata University
Japan

Keywords

Male, Fibrin, alpha-2-Antiplasmin, Fibrinolysis, Enzyme-Linked Immunosorbent Assay, Pancreatitis-Associated Proteins, Thrombophlebitis, Antifibrinolytic Agents, Thromboembolism, Acute Disease, Chronic Disease, Humans, Female, Fibrinolysin

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