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Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells

Name: Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells
Keywords: Cell Survival, Fluorescent Antibody Technique, Cell Differentiation, Extremities, Rats, Inbred Strains, Albendazole, Embryo, Mammalian, Immunohistochemistry, Microtubules, Rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1991 English Publisher:Elsevier BVJournal:Toxicology and Applied Pharmacology, volume 109, pages 73-84 (issn: 0041-008X,

Authors: Elaine M. Faustman; Stephen G. Whittaker;

doi: 10.1016/0041-008x(91)90192-h

pmid: 2038752

Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells

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Abstract

Micromass cell culture systems for rat embryo midbrain (CNS) and limb bud (LB) cells were employed to assess the in vitro developmental toxicity of the human and veterinary anthelmintic albendazole (ABZ) and its sulfoxide metabolite (SOABZ). ABZ is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. It has been postulated that SOABZ is the reactive metabolite responsible for albendazole's developmental toxicity and anthelmintic activity in vivo. Three parameters for assessing developmental toxicity were measured: cell growth, differentiation, and cytotoxicity. CNS and LB cultures were equivalent in their sensitivities to both ABZ and SOABZ. ABZ was approximately 50-fold more potent than SOABZ. Immunohistochemical determinations of tubulin organization revealed that both ABZ and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. Since ABZ is one of the most potent agents tested in the micromass system to date, this anthelmintic should be considered a potential developmental toxicant.

Related Organizations

University of Mary
United States
Washington State University
United States

Keywords

Cell Survival, Fluorescent Antibody Technique, Cell Differentiation, Extremities, Rats, Inbred Strains, Albendazole, Embryo, Mammalian, Immunohistochemistry, Microtubules, Rats, Mesencephalon, Neutral Red, Tubulin, Animals, Dimethyl Sulfoxide, Cells, Cultured

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