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Intermediates of stigmasterol metabolism in spodoptera littoralis

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1989 English Publisher:Elsevier BVJournal:Steroids, volume 53, pages 329-343 (issn: 0039-128X,

Authors: Huw H. Rees; Nigel Hoggard; Malcolm J. Thompson; James A. Svoboda;

doi: 10.1016/0039-128x(89)90018-4

pmid: 2799849

Intermediates of stigmasterol metabolism in spodoptera littoralis

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Abstract

Stigmasterol-24,28-epoxide, 22E-stigmasta-5,22,24(28E)-trien-3 beta-ol, and 22E-cholesta-5,22,24-trien-3 beta-ol were identified as normal metabolites of [3H]stigmasterol in Spodoptera littoralis larvae. Relative concentrations of all three of these metabolites increased when a diazasterol inhibitor was fed in combination with stigmasterol in the artificial diet. Identification of these sterols as intermediates in the conversion of stigmasterol to cholesterol in this insect indicates that intermediates analogous to fucosterol and fucosterol-24,28-epoxide in the conversion of sitosterol to cholesterol are produced in the metabolism of stigmasterol. This is the first published identification of stigmasterol-24,28-epoxide and 22E-stigmasta-5,22,24(28E)-trien-3 beta-ol as intermediates in this pathway in an insect.

Related Organizations

United States Department of the Interior
United States
University of Liverpool
United Kingdom

Keywords

Insecta, Desmosterol, Stigmasterol, Phytosterols, Tritium, Gas Chromatography-Mass Spectrometry, Mass Spectrometry, Diet, Sterols, Azasteroids, Animals, Chromatography, High Pressure Liquid

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Fields of Science (3) View all

medical and health sciences

basic medicine

Fields of Science

medical and health sciences

basic medicine

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