Neurologic manifestations of human immunodeficiency virus disease have been well documented and include peripheral neuropathy of the facial nerve. HIV-related peripheral facial nerve paralysis may be of predictive value in endemic populations, and it may be associated with acute HIV infection. It may herald the onset of seroconversion, and it is more common in the later stages of HIV disease. Treatment is palliative in nature and, although self-limiting, the condition may be of an extended duration and result in increased patient morbidity. The nutritional impact of HIV-related peripheral facial nerve paralysis on the patient and associated exacerbation of oral manifestations of HIV disease resulting from the presence of oral dryness are addressed. Early dental intervention is essential to reduce patient morbidity.