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Biomimetic pulmonary surfactants

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1994Publisher:Elsevier BVJournal:Life Sciences, volume 56, pages 363-378 (issn: 0024-3205,

Authors: Larry R. McLean; Jon E. Lewis;

doi: 10.1016/0024-3205(94)00902-3

pmid: 7830498

Biomimetic pulmonary surfactants

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Abstract

Considerable progress has been made in the development of defined mixtures of proteins or peptides with phospholipids which mimic the activity of natural pulmonary surfactants. Several of these biomimetic surfactants are active in animal models and clinical syndromes of surfactant deficiency. This review summarizes the structure and composition of natural surfactants and the development of defined mixtures of peptides and lipids that may be useful in the treatment of respiratory distress.

Related Organizations

Marion Merrell Dow
United States

Keywords

Male, Drug Design, Molecular Sequence Data, Humans, Female, Pulmonary Surfactants, Amino Acid Sequence, Designer Drugs

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	9
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average