Potentiation of stress-induced analgesia (SIA) by thiorphan and its block by naloxone
Copyright policy )Potentiation of stress-induced analgesia (SIA) by thiorphan and its block by naloxone
Exposure of rats to inescapable footshock produces an analgesic effect. To determine if endogenously released enkephalins play a role in this phenomenom, rats were treated with the enkephalinase inhibitor thiorphan (T), exposed to inescapable stress, and tested in the tail-flick test for antinociception. T (10-100 mg/kg sc) caused a dose-related potentiation of both the peak effect and the duration of the SIA. This effect was blocked by doses of naloxone (1 mg/kg sc) that did not affect baseline response latencies.
- Schering-Plough United States
Male, Thiorphan, Naloxone, Tiopronin, Pain, Rats, Inbred Strains, Enkephalins, Rats, Amino Acids, Sulfur, Stress, Physiological, Animals, Protease Inhibitors
Male, Thiorphan, Naloxone, Tiopronin, Pain, Rats, Inbred Strains, Enkephalins, Rats, Amino Acids, Sulfur, Stress, Physiological, Animals, Protease Inhibitors
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