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Enflurane biotransformation in humans

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1980 English Publisher:Elsevier BVJournal:Life Sciences, volume 27, pages 1,465-1,468 (issn: 0024-3205,

Authors: M.S. Miller; A.J. Gandolfi;

doi: 10.1016/0024-3205(80)90370-7

pmid: 7442453

Enflurane biotransformation in humans

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Abstract

Abstract The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatographic-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.

Keywords

Enflurane, Fluoroacetates, Humans, Chromatography, Ion Exchange, Biotransformation, Gas Chromatography-Mass Spectrometry

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