Human nerve growth factor: Lack of immunocrossreactivity with mouse nerve growth factor
Copyright policy )Human nerve growth factor: Lack of immunocrossreactivity with mouse nerve growth factor
Abstract Human β-nerve growth factor (hNGF) was purified from term human placenta. The biological potency of hNGF in the chick dorsal root ganglion assay did not differ significantly from that of mouse NGF (mNGF). Molecular weight determinations of mNGF and hMGF were also similar. No immunological crossreactivity was noted between hNGF, at a concentration of 100 μg/ml, and mNGF in a radioimmunoassay for mNGF using 6 different antisera to mNGF. hNGF shares several properties with mNGF but is immunological distinct. The results of studies in man using antisera to mNGF should be interpreted with caution.
- UCLA Medical Center United States
- UCLA Health United States
- Harbor–UCLA Medical Center United States
Male, Chromatography, Placenta, Cross Reactions, Mice, Species Specificity, Pregnancy, Animals, Humans, Female, Nerve Growth Factors
Male, Chromatography, Placenta, Cross Reactions, Mice, Species Specificity, Pregnancy, Animals, Humans, Female, Nerve Growth Factors
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