descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1978 English Publisher:Elsevier BVJournal:Life Sciences, volume 23, pages 1,481-1,486 (issn: 0024-3205,

Authors: James L. Meyerhoff; G.Jean Kant;

doi: 10.1016/0024-3205(78)90129-7

pmid: 713704

Release of endogenous dopamine from corpus striatum

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Abstract

Abstract The release of endogenous dopamine from a chopped rat striatal preparation was measured using a sensitive radio-enzymatic assay for dopamine. Either KC1 or d-amphetamine stimulated significant release of dopamine which was easily detected within one minute in this system. The amount of dopamine released was dependent upon the concentration of KC1 or d-amphetamine. The technique permits study of the initial, rapid phase of release of endogenous transmitter.

Related Organizations

Walter Reed Army Institute of Research
United States

Keywords

Male, Kinetics, Dextroamphetamine, Dopamine, Temperature, Animals, In Vitro Techniques, Corpus Striatum, Potassium Chloride, Rats

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