Name: The specificity of aminoacylation: a tRNA-tRNA interaction model
Creator: P, Lestienne
Keywords: Amino Acyl-tRNA Synthetases, Models, Molecular, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, RNA, Transfer, Mutation, Anticodon, RNA, Transfer, Amino Acyl, Models, Biological

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1978 English Publisher:Elsevier BVJournal:Journal of Theoretical Biology, volume 73, pages 159-180 (issn: 0022-5193,

Authors: P, Lestienne;

doi: 10.1016/0022-5193(78)90184-4

pmid: 249835

The specificity of aminoacylation: a tRNA-tRNA interaction model

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Abstract

Abstract Most of the isoacceptor species for a particular tRNA can be classified according to the middle base in the anticodon together with the fourth base in the amino acid stem. These specifying nucleotides would operate if a tRNA-tRNA interaction occurs on the aminoacyl-tRNA synthetase so that the anticodon of one tRNA molecule faces the fourth base of the other tRNA molecule. This model explains most of the misacylation reactions or changes in aminoacylation after mutation or chemical modifications of tRNAs. It also provides an explanation for biochemical properties of the aminoacyl-tRNA synthetases such as the presence of two active sites, and for the high fidelity of the aminoacylation. It may give insight into the origin and stability of the genetic code.

Related Organizations

UNIVERSITE MARIE ET LOUIS PASTEUR
France
Argonne National Laboratory
United States

Keywords

Amino Acyl-tRNA Synthetases, Models, Molecular, RNA, Transfer, Mutation, Anticodon, RNA, Transfer, Amino Acyl, Models, Biological

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