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pmid: 330960
A mechanism is proposed to explain how a mutation in a single molecule of mitochondrial DNA (mitDNA) can come to affect all the other mitDNA molecules of a yeast cell. It is suggested that an initial mutation may be “amplified” by a process which is, in fact, intended to ensure the identity of the cell's complement of mitDNA molecules. It is postulated that this process involves a small number of “reference” copies of mitDNA to which all other (“derived”) copies are compared and corrected once per cell cycle. Asymmetric gene conversion is proposed as the correction mechanism and the means of “amplifying” mutations. The model is shown to be compatible with current data on spontaneous and induced mitochondrial mutation in Saccharomyces cerevisiae.
DNA Replication, Recombination, Genetic, Genotype, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology; name=Manchester Institute of Biotechnology, Mutation, Saccharomyces cerevisiae, DNA, Mitochondrial, Models, Biological
DNA Replication, Recombination, Genetic, Genotype, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology; name=Manchester Institute of Biotechnology, Mutation, Saccharomyces cerevisiae, DNA, Mitochondrial, Models, Biological
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 6 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |