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Neuronal anti-nuclear antibody in paraneoplastic sensory neuronopathy

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1988Publisher:Elsevier BVJournal:Journal of the Neurological Sciences, volume 85, pages 1-8 (issn: 0022-510X,

Authors: David J. Dick; John Harris; John H. Xuereb; John B. Foster; Gavin Falkous;

doi: 10.1016/0022-510x(88)90030-5

pmid: 2838583

Neuronal anti-nuclear antibody in paraneoplastic sensory neuronopathy

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Abstract

Sera from 3 patients with a paraneoplastic sensory neuronopathy and small cell carcinoma of the lung were found to contain an IgG directed against neuronal nuclei and the nuclei of cells in adrenal medulla. Plasma from one of these patients was injected into laboratory mice for 100 days but passive transfer of the syndrome could not be effected. Plasma did not affect the viability of the dorsal root ganglia cells in tissue culture but did appear to bind to their nuclei. The role of this antibody remains uncertain.

Keywords

Lung Neoplasms, Paraneoplastic Syndromes, Fluorescent Antibody Technique, Middle Aged, Antibodies, Antinuclear, Ganglia, Spinal, Humans, Female, Neurons, Afferent, Carcinoma, Small Cell, Nervous System Diseases, Aged

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	33
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%