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Remyelination in the central diphtheria toxin lesion

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1972 English Publisher:Elsevier BVJournal:Journal of the Neurological Sciences, volume 17, pages 293-302 (issn: 0022-510X,

Authors: J. Ochoa; B.M. Harrison; W.I. McDonald;

doi: 10.1016/0022-510x(72)90034-2

pmid: 4653964

Remyelination in the central diphtheria toxin lesion

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Abstract

Abstract Criteria for the recognition of central remyelination are suggested, and the evidence for remyelination in experimental and human disease is critically reviewed. In the central diphtheria toxin lesion, remyelination of central axons by Schwann cells occurs, but there is no conclusive evidence for remyelination by glial cells. Appearances superficially resembling remyelination are produced by partial demyelination. Where remyelination does occur, it is incomplete. The relationship between incomplete remyelination and recovery of function is discussed.

Related Organizations

University College London Hospitals NHS Foundation Trust
United Kingdom
National Hospital for Neurology and Neurosurgery
United Kingdom

Keywords

Central Nervous System, Nerve Regeneration, Microscopy, Electron, Spinal Cord, Cats, Animals, Diphtheria Toxin, Schwann Cells, Neuroglia, Myelin Sheath, Demyelinating Diseases

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	74
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%