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A secreted calreticulin protein in ixodid tick (Amblyomma americanum) saliva

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1995 United States Publisher:Elsevier BVJournal:Journal of Insect Physiology, volume 41, pages 369-375 (issn: 0022-1910,

Authors: Acarology Laboratory, Department of Entomology, The Ohio State University W. 12th Avenue, Columbus, OH 43210, U.S.A. ( host institution ); Jaworski, Deborah C.; Simmen, Frank A.; Lamoreaux, William; Coons, Lewis B.; Muller, Mark T.; Needham, Glen R.;

doi: 10.1016/0022-1910(94)00107-r

A secreted calreticulin protein in ixodid tick (Amblyomma americanum) saliva

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Abstract

A complementary DNA clone from salivary glands of feeding female Amblyomma americanum ticks has been characterized as encoding calreticulin. Calreticulin, a major endoplasmic reticulum (ER) calcium-binding protein, appears to be secreted in Amblyomma and Dermacentor saliva. Evidence is accummulating that calreticulin performs roles unrelated to calcium storage. Unlike most known calreticulins, tick-secreted calreticulin lacks the ER retention signal, KDEL. This is the first molecular cloning of a specific tick salivary gland protein. The finding of a secreted calreticulin in tick saliva suggests a role for calreticulin in blood feeding through host immunosuppression or antihemostasis.

Country

United States

Related Organizations

The Ohio State University
United States
University of Memphis
United States
Florida Southern College
United States
The Ohio State University at Marion
United States

Keywords

Antihemostasisk, Calreticulin, Saliva, Immunosuppression, Tick

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