Irsogladine is a potent inhibitor of angiogenesis
Copyright policy )Irsogladine is a potent inhibitor of angiogenesis
We describe a novel inhibitor of angiogenesis, Irsogladine, an anti‐ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.
- Oita University Japan
Neovascularization, Pathologic, Triazines, Plasminogen activator, Mice, Enzyme Induction, Tissue Plasminogen Activator, Animals, Humans, Angiogenesis, Endothelium, Vascular, Cells, Cultured, Irsogladine
Neovascularization, Pathologic, Triazines, Plasminogen activator, Mice, Enzyme Induction, Tissue Plasminogen Activator, Animals, Humans, Angiogenesis, Endothelium, Vascular, Cells, Cultured, Irsogladine
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