Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor
Copyright policy )Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor
Insulin administration to rats produced a dose-related hypoglycemia. When insulin and the enkephalinase (Enk'ase) inhibitor thiorphan (30 or 100 mg/kg s.c.) were co-administered, there was a potentiation of the hypoglycemic response to insulin; these doses of thiorphan alone had no significant effect on plasma glucose. When tested in vitro against isolated Enk'ase, both insulin and its beta-chain inhibited the catabolism of [Met5]enkephalin. Theoretically, thiorphan blocked the catabolism of insulin by inhibiting Enk'ase. Alternatively, thiorphan acted as an inhibitor of another insulin-catabolizing enzyme having similar substrate requirements as Enk'ase.
Blood Glucose, Male, Thiorphan, Enkephalin, Methionine, Tiopronin, Brain, Drug Synergism, Rats, Inbred Strains, Rats, Amino Acids, Sulfur, Animals, Insulin, Neprilysin, Protease Inhibitors
Blood Glucose, Male, Thiorphan, Enkephalin, Methionine, Tiopronin, Brain, Drug Synergism, Rats, Inbred Strains, Rats, Amino Acids, Sulfur, Animals, Insulin, Neprilysin, Protease Inhibitors
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