The potentiation of spinal analgesia by leucine enkephalin
Copyright policy )The potentiation of spinal analgesia by leucine enkephalin
In two strains of rats, intrathecal administration of morphine and met-enkephalin was found to produce a dose-dependent analgesic effect as measured by the tail-flick assay. Prior administration of leu-enkelphalin at a dose which had no analgesic effect was found to reduce significantly the analgesic ED50 of both morphine and met-enkephalin. Met-enkephalin pretreatment, at a similar sub-analgesic dose, was without effect. Thus, a differential interaction of the enkephalins with morphine is evident at spinal structures.
- University of Minnesota System United States
- Rutgers, The State University of New Jersey United States
- University of Minnesota United States
- University of Minnesota Morris United States
Male, Dose-Response Relationship, Drug, Morphine, Drug Synergism, Enkephalins, Anesthesia, Spinal, Rats, Reaction Time, Animals, Injections, Spinal, Enkephalin, Leucine
Male, Dose-Response Relationship, Drug, Morphine, Drug Synergism, Enkephalins, Anesthesia, Spinal, Rats, Reaction Time, Animals, Injections, Spinal, Enkephalin, Leucine
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