descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1981 English Publisher:Elsevier BVJournal:Brain Research, volume 210, pages 441-448 (issn: 0006-8993,

Authors: Marian W. Kies; Fredrick J. Seil; Martha L. Bacon;

doi: 10.1016/0006-8993(81)90924-0

pmid: 6164446

A comparison of demyelinating and myelination-inhibiting factor induction by whole peripheral nerve tissue and P2 protein

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Abstract

Sera from rabbits sensitized with whole bovine spinal roots demyelinated and inhibited myelination in both peripheral and central nervous system tissue cultures. Antisera directed against the peripheral nerve myelin basic protein, P2, demonstrated no antimyelin activity in vitro. These results suggest that demyelinating and myelination-inhibiting factors are directed against some peripheral nerve component(s) other than the P2 protein.

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Keywords

Immunoassay, Immune Sera, Myelin Basic Protein, Embryo, Mammalian, Myelin P2 Protein, Mice, Spinal Cord, Animals, Cattle, Peripheral Nerves, Cells, Cultured, Myelin Sheath

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