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CSF creatinine in schizophrenia

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1988 English Publisher:Elsevier BVJournal:Biological Psychiatry, volume 23, pages 586-594 (issn: 0006-3223,

Authors: Göran Sedvall; Carl-Gunnar Swahn;

doi: 10.1016/0006-3223(88)90005-4

pmid: 2451543

CSF creatinine in schizophrenia

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Abstract

Concentrations of creatinine in cerebrospinal fluid (CSF) from schizophrenic patients and healthy control subjects were determined by a liquid chromatographic method. The concentration of creatinine in CSF from schizophrenic patients was lower (42.8 nmol/ml) than that of the controls (54.4 nmol/ml). The concentration of creatinine was correlated to the levels of homovanillic acid and 5-hydroxyindoleacetic acid. Treatment of the schizophrenic patients with sulpiride (800 mg daily), but not with chlorpromazine, elevated the concentration of creatinine in the CSF.

Related Organizations

Karolinska Institute
Sweden

Keywords

Adult, Male, Homovanillic Acid, Hydroxyindoleacetic Acid, Middle Aged, Methoxyhydroxyphenylglycol, Blood-Brain Barrier, Creatinine, Schizophrenia, Humans, Female

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
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