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Quinobene, a new potent anti-HIV agent

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1992Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 187, pages 1,409-1,417 (issn: 0006-291X,

Authors: Ewa Gruszecka-Kowalik; Rudiger D. Haugwitz; Leon H. Zalkow;

doi: 10.1016/0006-291x(92)90459-x

pmid: 1417817

Quinobene, a new potent anti-HIV agent

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Abstract

A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound. The lithium and tetramethylammonium salts of Quinobene and its complexes with Cu(II), Zn(II), Mg(II) were also prepared. In vitro tests showed considerable activity of these compounds against HIV-1.

Related Organizations

Georgia Institute of Technology
United States

Keywords

Stilbenes, HIV, Humans, In Vitro Techniques, Virus Replication, Antiviral Agents, Azo Compounds, Cells, Cultured, Chelating Agents

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