descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1981 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 99, pages 768-774 (issn: 0006-291X,

Authors: John J. Langone; Regina Ejzemberg;

doi: 10.1016/0006-291x(81)91231-6

pmid: 7247942

Succinylated and acetylated concanavalin A activate the classical complement pathway

- Summary
- Subjects
- Metrics

Abstract

Abstract Succinylated and acetylated concanavalin A, but not the native lectin, lyse sheep erythrocytes in the presence of guinea pig complement. The effect appears to be specific since succinylated wheat germ agglutinin is inactive and hemolysis is inhibited selectively by α-D-methylglucopyranoside. Hemolytic activity is enhanced by preincubation of succinylated lectin-sensitized cells with complement at 4° and correlates with the number of molecules of the first component of complement bound to cells that were treated with succinylated concanavalin A and then washed.

Related Organizations

National Institute of Health
Pakistan

Keywords

Erythrocytes, Sheep, Dose-Response Relationship, Drug, Wheat Germ Agglutinins, Complement Fixation Tests, Guinea Pigs, Methylglucosides, Hemolysis, Complement C1, Lectins, Concanavalin A, Animals, Complement Pathway, Classical, Complement Activation

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	2
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average