The stereochemistry of pyruvate kinase
Copyright policy )The stereochemistry of pyruvate kinase
Abstract α-Ketobutyrate enol phosphate consisting of approximately 80% cis and 20% trans isomers was prepared by the Perkow reaction. It was converted by pyruvate kinase in 2H2O, to α-ketobutyrate which on oxidative decarboxylation with hydrogen peroxide gave largely (2 R )-2- 2 H-propionate containing one atom of deuterium. It was concluded that protonation in the pyruvate kinase reaction occurred on the si face with cis -α-ketobutyrate enol phosphate as substrate, and probably also with the trans isomer.
- Columbia University United States
- New York University United States
Magnetic Resonance Spectroscopy, Chemical Phenomena, Muscles, Pyruvate Kinase, Stereoisomerism, Hydrogen Peroxide, Deuterium, Decarboxylation, Keto Acids, Butyrates, Chemistry, Animals, Phosphoric Acids, Rabbits, Propionates, Protons, Oxidation-Reduction
Magnetic Resonance Spectroscopy, Chemical Phenomena, Muscles, Pyruvate Kinase, Stereoisomerism, Hydrogen Peroxide, Deuterium, Decarboxylation, Keto Acids, Butyrates, Chemistry, Animals, Phosphoric Acids, Rabbits, Propionates, Protons, Oxidation-Reduction
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