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Biochimica et Biophysica Acta (BBA) - Enzymology
Article . 1978 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Biochimica et Biophysica Acta
Article . 1978
Data sources: Europe PubMed Central
Biochimica et Biophysica Acta
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Effects of melanin on tyrosine hydroxylase and phenylalanine hydroxylase

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1978Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Enzymology, volume 523, pages 47-52 (issn: 0005-2744, Copyright policy )
Authors: Kenji Sugiyama; Miki Akino; Yukiko Numata; Takeshi Kato; Toshiharu Nagatsu;

doi: 10.1016/0005-2744(78)90007-4

pmid: 24474

Effects of melanin on tyrosine hydroxylase and phenylalanine hydroxylase

Abstract

Melanin inhibited rat liver phenylalanine hydroxylase, but activated tyrosine hydroxylase from rat brain (caudate nucleus), rat adrenal glands, and bovine adrenal medulla. Activation of tyrosine hydroxylase by melanin was demonstrated with the extensively dialyzed enzyme and in suboptimal concentrations of the substrate (tyrosine) and the cofactor (6-methyltetrahydropterin). Tyrosine hydroxylase from rat brain was activated by melanin more markedly than that from rat adrenal glands. Purified and extensively dialyzed bovine adrenal tyrosine hydroxylase had two Km values with 6-methyltetrahydropterin, depending upon its concentrations, but the melanin-activated tyrosine hydroxylase had a single Km value and showed the classical Michaelis-Menten kinetics.

Related Organizations
Keywords

Melanins, Tyrosine 3-Monooxygenase, Phenylalanine Hydroxylase, Rats, Kinetics, Liver, Species Specificity, Organ Specificity, Adrenal Glands, Animals, Cattle, Caudate Nucleus

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    		 22
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
22
Average
Top 10%
Top 10%
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