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Net adenosine diphosphate accumulation in mitochondria

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1977Publisher:Elsevier BVJournal:Archives of Biochemistry and Biophysics, volume 183, pages 581-587 (issn: 0003-9861,

Authors: S. Abou-Khalil; J.B. Hanson;

doi: 10.1016/0003-9861(77)90393-9

pmid: 921279

Net adenosine diphosphate accumulation in mitochondria

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Abstract

Abstract In addition to the adenine nucleotide exchange translocator, corn mitochondria possess a transport mechanism for the net accumulation of [3H]ADP. The accumulation is energy linked and requires the presence of phosphate and Mg2+. Inhibition of the adenine nucleotide exchange translocator with carboxyatractyloside does not block ADP accumulation; rather, accumulation is slightly promoted. Mersalyl, by inhibiting the influx of phosphate or the efflux from phosphate-loaded mitochondria, very effectively blocks ADP accumulation. The data suggest that the net uptake of ADP is in exchange for accumulated phosphate by means of a mersalyl-sensitive transporter. Magnesium promotes phosphate accumulation, but it may have an additional role in facilitating ADP accumulation.

Related Organizations

University of Illinois at Urbana Champaign
United States
University of Illinois System
United States

Keywords

Biological Transport, Active, Atractyloside, Plants, Zea mays, Mitochondria, Phosphates, Adenosine Diphosphate, Kinetics, Oxygen Consumption, Magnesium

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