Abstract Six patients with perforated diverticula of the transverse colon were treated at the Menorah Medical Center. Acute appendicitis was suspected preoperatively in four patients, acute peritonitis caused by a lesion of the descending colon was suspected in one patient, and one patient was thought to have a carcinoma or perforated diverticulum. Segmental resection of the diverticular mass of the transverse colon was performed in five patients and ileotransverse colectomy in one patient. All patients recovered without complication. This condition, although rare, should be kept in mind particularly during “negative” exploration for acute appendicitis.