Abstract 1. 1. Leiomyosarcoma of the jejunum is a rare tumor and is invariably fatal unless subjected to early definitive surgical treatment. 2. 2. Delay in diagnosis of this neoplasm has occurred frequently in the past and is explained by the vague character of initial symptoms. When there is coincidental disease of the gallbladder, duodenum and stomach or colon, the symptomatology is frequently confusing and treatment may be misdirected. 3. 3. Unexplained anemia, weight loss, weakness, anorexia, vomiting or abdominal pain are indications for a thorough roentgenologic study of the small bowel and careful roentgenographic technic should establish a correct diagnosis of jejunal malignancy in a majority of cases. When such late evidences of leiomyosarcoma of the jejunum as hemorrhage, obstruction or abdominal mass are present, surgical intervention is mandatory. 4. 4. Radical resection of the jejunal neoplasm, together with the regional lymphatics, can be curative. Surgical treatment may be expected to afford considerable symptomatic relief even in many patients in whom the disease is obviously far advanced. 5. 5. Earlier diagnosis of leiomyosarcoma of the jejunum will lead to improvement in the over-all survival rate in this disease.