Abstract A case of angiosarcoma of the sternum has been presented in which radiation therapy was followed by radical excision of the manubrium and upper part of the sternum. The patient made a rapid recovery from the operation without impairment of function. In spite of the radiosensitivity of the tumor the complete excision of the tumor mass and surrounding tissues and the apparent complete recovery of the patient after surgery, metastases occurred to the skull and left humerus, and death ensued within eighteen months from the onset of the symptoms. A brief review of the literature and histologic diagnosis of angiosarcoma has been included.