descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1977 English Publisher:Elsevier BVJournal:American Journal of Ophthalmology, volume 83, pages 862-865 (issn: 0002-9394,

Authors: Robert A. Moses; Marvin F. Feldman;

doi: 10.1016/0002-9394(77)90915-1

pmid: 326055

Corneal Penetration of Rifampin

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Abstract

We tested the corneal penetration of rifampin in four vehicles: dimethylsulfoxide, polyethylene glycol, an ocular lubricant, and as rifampin ointment. We measured drug concentrations in the aqueous humor in rabbits after topical instillation of 1 and 2.5% rifampin according to two dosage schedules. Drug concentrations in the aqueous humor were bactericidal to Mycobacterium leprae. Since leprosy of the cornea, iris, and ciliary body may develop despite standard systemic bacteriostatic treatment, treatment of leprotic involvement of the anterior eye may be enhanced by intensive topical application of rifampin.

Related Organizations

University of Mary
United States
Washington University in St. Louis
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Keywords

Chlorobutanol, Keratitis, Lanolin, Petrolatum, Administration, Topical, Ciliary Body, Iris, Drug Administration Schedule, Polyethylene Glycols, Aqueous Humor, Cornea, Mycobacterium leprae, Ointments, Drug Combinations, Leprosy, Animals, Mineral Oil, Dimethyl Sulfoxide, Rabbits, Pharmaceutical Vehicles

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