Abstract This report includes an analysis of the clinical records of 132 patients with the diagnosis of irregular shedding of the endometrium by curettage timed to the fifth day or later of the menstrual period. The entire group was divided into a smaller group of 33 patients who had classical symptoms of irregular shedding without associated gynecologic pathology and a larger residual group of 99 patients who are designated as having atypical symptoms. Comparison of the two groups reveals differences that for the most part can be explained by the presence of associated pathology. We agree with previous observers who feel that irregular shedding is a clinical entity that may exercise its dysfunctional effect with or without associated gynecologic pathology. A group of 5 patients were observed in a study clinic with basal temperature records employed as a control for estrogenic therapy. Review of the temperature records before therapy showed that bleeding occurred earlier in the corpus luteum phase than is normally expected. This is interpreted as break-through bleeding possibly due to abnormal endometrial response to normal progesterone levels. Postovulatory stilbestrol therapy was employed with good hemostatic effect but without shortening the length of the bleeding period.