S inus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease, is a benign pseudolymphomatous entity with distinct clinical and pathologic features [l-3]. This disorder, usually occurring during the first two decades of life, is manifested by massive, painless cervical lymphadenopathy in association with fever, leukocytosis with neutrophilia, increased erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. Histopathologically, the involved lymph nodes show extensive proliferation of cytophagic histiocytes within distended sinuses. Cases in which similar pathologic involvement of extranodal sites resulted in clinical manifestations have been described [a]. The exact cause and pathogenesis of this condition remain unknown. This case report describes a young patient with nodal, skeletal, and probable nasal involvement of sinus histiocytosis with massive lymphadenopathy in association with serologic evidence of recent Brucella infection.