Abstract A nomogram is described for developing loading and maintenance dosage regimens of digoxin for adult euthyrold patients with reasonably normal hepatic function, in normal electrolyte balance, who have no obvious abnormality of gastrointestinal absorption. The nomogram relates observed data of risk of adverse reactions, risk of arrhythmias, serum digoxin levels, calculated maximum total body digoxin concentrations, body weight, total oral loading dose, data of renal function and daily maintenance dose. Physicians may select an acceptable risk or peak serum level depending upon each patient's clinical status, and then develop a loading and maintenance dosage regimen to consider giving, adjusted to the patient's body weight and renal function, to achieve one's selected therapeutic goals with reasonable accuracy for most patients most of the time.