Digitalis tolerance during atrial fibrillation and normal sinus rhythm
Copyright policy )Digitalis tolerance during atrial fibrillation and normal sinus rhythm
Abstract In each of 9 normal dogs the toxic dose of acetylstrophanthidin was determined on three separate occasions during normal sinus rhythm and atrial fibrillation. During atrial fibrillation the mean toxic dose was 10 to 30 per cent (average 21%) greater than that recorded in the same animal during normal sinus rhythm. The increased tolerance to acetylstrophanthidin during atrial fibrillation was not a function of the ventricular rate immediately before the occurrence of toxicity. The study provides an indirect explanation for the manifestations of digitalis intoxication that sometimes follow the restoration of normal sinus rhythm in digitalized patients with atrial fibrillation.
Dogs, Dose-Response Relationship, Drug, Heart Rate, Reference Values, Heart Ventricles, Atrial Fibrillation, Animals, Digitalis Glycosides, Strophanthidin, Drug Tolerance, Sinoatrial Node
Dogs, Dose-Response Relationship, Drug, Heart Rate, Reference Values, Heart Ventricles, Atrial Fibrillation, Animals, Digitalis Glycosides, Strophanthidin, Drug Tolerance, Sinoatrial Node
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