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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao American Heart Journ...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
American Heart Journal
Article . 1992 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Verapamil-induced gingival hyperplasia in children

Authors: Mehta, Ashok V.; Chidambaram, Balasubrahmanyam; O'Riordan, Anna C.;

Verapamil-induced gingival hyperplasia in children

Abstract

Gingival hyperplasia (GH) occurs in 20 % to 40 So of all patients receiving long-term oral phenytoin therapy and phenytoin is probably the most common cause of GH in children and young ado1escents.l Several other drugs including nifedipine, a calcium channel blocker, have been reported infrequently to cause GH.2-4 We report here a similar GH in two children following the long-term administration of a large dose of verapamil for the management of supraventricular tachycardia (SVT). Verapamil-associated GH has not been reported previously in the English literature. Case Ntj. 1. SL is a 12-year-old girl who was first noted to have tachycardia during the prenatal period. She had a trial of digoxin, quinidine, and propranolol in high doses in various combinations, with partial control of her SVT. At 3 years of age, a diagnosis of a permanent form of junctional reciprocating tachycardia (long R-P’ tachycardia) was made by electrophysiologic study, and an intravenous verapamil trial (0.2 mg/kg) was successful. She had no ventricular dysfunction by echocardiography. She was started on oral verapamil, 80 mg twice a day (9 mg/kg/day), with partial control, and was maintained on a similar dose with respect to body weight for the next 4 years. At 7 years of age, she was changed to sustained-release verapamil, 240 mg twice a day (15 mg/kg/day). Following 2 weeks of therapy on this dose, her verapamil level was 1030 Fg/L and 590 PglL at 6 hours and 12 hours, respectively, after the oral dose of verapamil (therapeutic trough level 100 to 600 pg/ L). Following 6 weeks of verapamil therapy, she developed marked GH. The labial gingivae of the anterior maxillary and mandibular teeth were firm, red, and nodular, with minimal bleeding. Despite good dental hygiene and frequent dental visits, she had persistent GH. There were no other adverse effects of verapamil. At 11 years of age verapamil was discontinued because of partial control of the tachycardia. Six weeks later her GH significantly improved. Subsequently she was started on a regimen of oral propafenone without success. At present she is maintained on a regimen of oral Aecainide with fairly good control of the tachycardia. Case No. 2. DM is a 16-year-old young woman patient who was noted to have a tachycardia during the prenatal

Country
United States
Keywords

Time Factors, Adolescent, Verapamil, Gingival Hyperplasia, Tachycardia, Supraventricular, Humans, Female, Child

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    15
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
15
Average
Top 10%
Average
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