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The efficacy of treatment with albendazole

Name: The efficacy of treatment with albendazole
Keywords: Adult, Male, Ascariasis, Hookworm Infections, Adolescent, Humans, Female, Trichuriasis, Intestinal Diseases, Parasitic, Middle Aged

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1991 English Publisher:Elsevier BVJournal:Acta Tropica, volume 50, pages 111-114 (issn: 0001-706X,

Authors: R.G. Mathias; K. Hanjeet;

doi: 10.1016/0001-706x(91)90003-3

pmid: 1685866

The efficacy of treatment with albendazole

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Abstract

Albendazole, a benzimidazole derivative, was administered as a single dose of either 400 mg or 600 mg to two groups to ascertain the efficacy, tolerance and safety of the regimens. At a dose of 400 mg, a cure rate 35/36 (97%) against Ascaris was found. At 600 mg, the cure rate was 21/30 (70%), significantly lower than the 400 mg rate. Against Trichuris, albendazole at 400 mg had a cure rate of 21/48 (44%), at 600 mg there was a cure rate of 29/43 (67%). Mild side effects were noted in 7 individuals. Whether the moderate increase in efficacy against Trichuris and the loss of efficacy against Ascaris improves the cost:benefit ratio must be left to the prescriber of the drug.

Related Organizations

University of British Columbia
Canada
Institute for Medical Research
Malaysia

Keywords

Adult, Male, Ascariasis, Hookworm Infections, Adolescent, Humans, Female, Trichuriasis, Intestinal Diseases, Parasitic, Middle Aged, Albendazole, Child

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