Entrepreneurship represents among the most complex of human mental activities, requiring a multitude of higher orders of functioning, such as motivation, endurance, resiliency, confidence, intelligence, leadership, agility, creativity, and innovation. Entrepreneurs envision in their minds the possibility of a future state, and work to actualize that vision into reality. The economist Joseph Schumpeter provided key contributions to entrepreneurship theory which are still applicable today, when he introduced two fundamental ideas: that innovation drives the growth of economies and of capital markets, and the person responsible for this innovation is the entrepreneur [1]. These Schumpeterian qualities of starting a venture by innovating and having the desire to grow serve as the distinguishing characteristics that identify an entrepreneur, in contrast to those individuals who work in already-established businesses or in self-employment settings where there are no plans for scalability [2]. The rise of the Internet in the 1990s followed by the evolution in the 2000s of the next wave of innovations including mobile technology, social networking, and cloud computing has created new frontiers at the interface of health and entrepreneurial activity. The Global Entrepreneurship Monitor 2013 United States Report estimates that in 2013, there were 25 million Americans starting up or working in new businesses, with about 13 % of the US working population doing these activities [3]. Entrepreneurship is generally recognized on the global scale as being central to the development and sustainability of economic prosperity, geopolitical stability, and improved standards of living. Understanding the mental health challenges in entrepreneurship can promote wellness both at the individual level and also grow alongside the ventures to have societal impact far beyond the scale of any single person.