Name: Angiotensin II and the glomerulus: Focus on diabetic kidney disease
Creator: James W, Scholey
Keywords: Renin-Angiotensin System, Angiotensin Receptor Antagonists, 03 medical and health sciences, 0302 clinical medicine, Diabetes Mellitus, Type 2, Angiotensin II, Kidney Glomerulus, Disease Progression, Animals, Humans

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2003 English Publisher:Springer Science and Business Media LLCJournal:Current Hypertension Reports, volume 5, pages 172-180 (issn: 1522-6417, eissn: 1534-3111,

Authors: James W, Scholey;

doi: 10.1007/s11906-003-0075-0

pmid: 12642018

Angiotensin II and the glomerulus: Focus on diabetic kidney disease

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Abstract

The renin-angiotensin system plays a key role in the progression of kidney disease, in addition to its well-described role in the maintenance of extracellular fluid volume and blood pressure. Recent studies have shown that blockade of the renin-angiotensin system at the level of the angiotensin II type 1 receptor can have important effects on proteinuria and the rate of progression of kidney disease in patients with type 2 diabetes mellitus. This review first discusses recent experimental studies relating angiotensin II to kidney function in diabetes mellitus and changes in glomerular permselectivity, and then focuses on recent clinical trials with angiotensin II receptor blockers in patients with type 2 diabetes mellitus.

Related Organizations

University of Toronto
Canada
Toronto General Hospital
Canada

Keywords

Renin-Angiotensin System, Angiotensin Receptor Antagonists, Diabetes Mellitus, Type 2, Angiotensin II, Kidney Glomerulus, Disease Progression, Animals, Humans, Diabetic Nephropathies

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