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Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through promotion of acentrosomal pole assembly

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2010Publisher:Springer Science and Business Media LLCJournal:Science China Life Sciences, volume 53, pages 1,322-1,329 (issn: 1674-7305, eissn: 1869-1889,

Authors: Jingyan Fu; Chuanmao Zhang; Yan Yan; Qing Jiang; Minglei Bian; QingHua Shi; Qiang Chen; +1 Authors

doi: 10.1007/s11427-010-4086-1

pmid: 21046324

Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through promotion of acentrosomal pole assembly

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Abstract

Paclitaxel is a widely used microtubule drug and cancer medicine. Here we report that by short exposure to paclitaxel at a low dose, multipolar spindles were induced in mitotic cells without centrosome amplification. Both TPX2 depletion and Aurora-A overexpression antagonized the multipolarity. Live cell imaging showed that some paclitaxel-treated cells accomplished multipolar cell division and a portion of the daughter cells went on to the next round of mitosis. The surviving cells grew into clones with varied genome content. The results indicated that an aneuploidy population could be induced by short exposure to paclitaxel at a low dose, implicating potential side effects of paclitaxel.

Related Organizations

University of Science and Technology of China
China (People's Republic of)
Peking University
China (People's Republic of)
Peking University
China (People's Republic of)

Keywords

Centrosome, Male, Paclitaxel, Mitosis, Nuclear Proteins, Cell Cycle Proteins, Spindle Apparatus, Protein Serine-Threonine Kinases, Aneuploidy, Tubulin Modulators, Mice, Inbred C57BL, Mice, Aurora Kinases, Animals, Humans, Microtubule-Associated Proteins, Aurora Kinase A, HeLa Cells

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