AbstractExistence results for a Cauchy problem driven by a semilinear differential Sturm-Liouville inclusion are achived by proving, in a preliminary way, an existence theorem for a suitable integral inclusion. In order to obtain this proposition we use a recent fixed point theorem that allows us to work with the weak topology and the De Blasi measure of weak noncompactness. So we avoid requests of compactness on the multivalued terms. Then, by requiring different properties on the map p involved in the Sturm-Liouville inclusion, we are able to establish the existence of both mild solutions and strong ones for the problem examinated. Moreover we focus our attention on the study of controllability for a Cauchy problem governed by a suitable Sturm-Liouville equation. Finally we precise that our results are able to study problems involving a more general version of a semilinear differential Sturm-Liouville inclusion.