Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity
Copyright policy )Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity
Alpha-synuclein aggregation and cytotoxicity are widely considered to play a critical role in the process of Parkinson's disease. Heat shock proteins are a large family of cellular protective molecules in most kinds of cells. In this study, we examined the impact of dominant-positive heat shock transcription factor 1 (HSF1) on alpha-synuclein over-expression cellular model of Parkinson's disease. We found that over-expression of alpha-synuclein could form alpha-synuclein immunopositive inclusions and result in cell death; dominant-positive HSF1 dramatically increased the expression of HSP70 in SH-SY5Y cells, and significantly decreased the level and cytotoxicity of alpha-synuclein. Taken together, these data indicate that dominant-positive HSF1 plays an important role in suppressing alpha-synuclein aggregation and toxicity in SH-SY5Y cells. Parkinson's disease which is marked by alpha-synuclein aggregation may be treated by increasing a set of endogenous heat shock proteins.
- University of Science and Technology of China China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
DNA-Binding Proteins, Heat Shock Transcription Factors, Cytoprotection, Cell Line, Tumor, alpha-Synuclein, Humans, HSP70 Heat-Shock Proteins, Promoter Regions, Genetic, Protein Structure, Quaternary, Genes, Dominant, Transcription Factors
DNA-Binding Proteins, Heat Shock Transcription Factors, Cytoprotection, Cell Line, Tumor, alpha-Synuclein, Humans, HSP70 Heat-Shock Proteins, Promoter Regions, Genetic, Protein Structure, Quaternary, Genes, Dominant, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).37 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!