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Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome

descriptionPublicationkeyboard_double_arrow_right Article 08 Nov 2012 English Publisher:Oxford University Press (OUP)Journal:Modern Rheumatology, volume 23, pages 841-845 (issn: 1439-7595, eissn: 1439-7609,

Authors: Hiromitsu Asashima; Mana Iizuka; Isao Matsumoto; Hiroto Tsuboi; Takayuki Sumida;

doi: 10.1007/s10165-012-0788-5 , 10.3109/s10165-012-0788-5

pmid: 23135882

Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome

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Abstract

Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations suggest the possibility that anti-M3R antibodies could serve as a new diagnostic test in patients with SS. Some anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, strategies designed to eliminate such pathogenic antibodies could help cure SS sufferers. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B cell epitopes and the function of anti-M3R antibodies.

Related Organizations

University of Tsukuba
Japan

Keywords

Receptor, Muscarinic M3, Sjogren's Syndrome, Epitopes, B-Lymphocyte, Humans, Autoantibodies

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