Magnetic resonance relaxometry in Parkinson's disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2002Publisher:Springer Science and Business Media LLCJournal:Neurological Sciences, volume 23, pages s87-s88 (issn: 1590-1874, eissn: 1590-3478,

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Authors: F, Mondino; P, Filippi; U, Magliola; S, Duca;

doi: 10.1007/s100720200083

pmid: 12548357

Magnetic resonance relaxometry in Parkinson's disease

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Abstract

A central role of iron in the pathogenesis of idiopathic Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and its capacity to enhance production of toxin reactive oxygen radicals, has been discussed for many years. Nuclear magnetic resonance (NMR) relaxation is considered an objective and noninvasive method of measuring regional iron concentrations. By means of this technique we investigated both controls and PD patients.

Keywords

Adult, Aged, 80 and over, Male, Iron, Brain, Parkinson Disease, Middle Aged, Magnetic Resonance Imaging, Case-Control Studies, Humans, Female, Aged

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