Effects of bilobalide on amino acid release and electrophysiology of cortical slices
Copyright policy )Effects of bilobalide on amino acid release and electrophysiology of cortical slices
This study investigated the effects of bilobalide, a constituent of Ginkgo biloba, on potassium and veratridine-induced release of glutamate and aspartate from mouse cortical slices. We also studied its effects on spontaneous and N-methyl-D-aspartate (NMDA)-induced depolarizations elicited in magnesium-free artificial cerebrospinal fluid (aCSF) as well as its effect on NO-711 (a gamma-aminobutyric acid (GABA) uptake inhibitor)-induced depolarizations. Bilobalide, 100 microM significantly reduced both glutamate and aspartate release elicited by potassium or veratridine. Bilobalide (5-100 microM) also significantly reduced the frequency of NO-711 induced depolarizations, however, it had no effect on spontaneous or on NMDA-induced depolarizations at 5-200 microM. These results suggest that the neuroactive properties of bilobalide may be mediated by a reduction in excitatory amino acid neurotransmitter release.
- University of Wales United Kingdom
Cerebral Cortex, Aspartic Acid, Mice, Inbred BALB C, Neurotransmitter Agents, N-Methylaspartate, Nipecotic Acids, Glutamic Acid, Cyclopentanes, In Vitro Techniques, Electrophysiology, Mice, Ginkgolides, Mice, Inbred DBA, Oximes, Potassium, Animals, Magnesium, Neurotransmitter Uptake Inhibitors, Diterpenes, Furans
Cerebral Cortex, Aspartic Acid, Mice, Inbred BALB C, Neurotransmitter Agents, N-Methylaspartate, Nipecotic Acids, Glutamic Acid, Cyclopentanes, In Vitro Techniques, Electrophysiology, Mice, Ginkgolides, Mice, Inbred DBA, Oximes, Potassium, Animals, Magnesium, Neurotransmitter Uptake Inhibitors, Diterpenes, Furans
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