Structural dynamics, an intrinsic property of viral capsids

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2001Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 146, pages 2,263-2,274 (issn: 0304-8608, eissn: 1432-8798,

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Authors: J, Witz; F, Brown;

doi: 10.1007/s007050170001

pmid: 11811678

Structural dynamics, an intrinsic property of viral capsids

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Abstract

In this review, we emphasize that high-resolution models of the structures of small plant and animal viruses obtained by X-ray crystallography are static and insufficient to describe the behavior of these virions. Viral capsids are highly flexible and may undergo conformational changes under physiological conditions without collapse of the virions. This flexibility plays a key role in the process of infection.

Related Organizations

United States Department of Agriculture
United States
Centre national de la recherche scientifique
France
Plum Island Animal Disease Center
United States

Keywords

Microscopy, Electron, Capsid, RNA Virus Infections, Animals, Humans, RNA Viruses, Crystallography, X-Ray, Plant Diseases, Plant Viruses

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