Abstract Biosensors provide immense promise for detecting and assessing numerous anomalies in the human body. Pancreatic disorders are also the main cause of various abnormalities in the body caused by diabetes, and lung cancer (LC) is the leading cause of cancer-related mortality worldwide, making it a major cause of death and a major obstacle to raising life expectancy in all countries. Introducing non-invasive diagnosis revolutionized the early detection of disease or abnormalities in medicine by capturing biomarkers. Saliva, perspiration, urea, bodily fluids, and exhaled breath can be used for the bloodless diagnosis. The ideal system may have several volatile organic compounds (VOC) sensors, electronic signal conditioning circuits to extract signals from the sensors, a processing unit, and software for data analysis. This study reports the potential of glassy carbon electrode material prepared using carbon microelectromechanical systems (C-MEMS) with a TiO\((_2)\) sensing channel. The sensor was developed to detect acetone as a target molecule to diagnose abnormalities in the human body. This approach led to stable and reliable advances in the development of biosensors to detect VOC at room temperature, at a cost-effective cost.